What drugs to take? This can get confusing. The problem is lots of different protective (prophylactic) drugs with all sorts of trade names and the fact that resistance to some of them is a very real problem, especially here in Southern Africa. Realistically you shouldn't bother with chloroquine or Paludrine by themselves anymore. More useful is Doxycycline. You start taking it daily a week before you leave and for four weeks after you return.
Mefloquine (also known as Lariam) is effective but but about 1 in 140 people taking the drug will have bad hallucinations.
The latest drug is Malarone, (called Melanil in South Africa) which seems to have few side-effects. Doctors recommend it for short trips because you don't need to take it more than 24 hours in advance to get protection and you can stop taking it seven days after you get back. You take it daily.
Finally, Artemisinin is the drug everyone is talking about. This curative drug (rather than preventative) is often found in chemists in African countries north of South Africa. It's kind to your system, but little formal research has been done on it. Many regular travellers into Africa swear by it, but doctors suggest it's effective mainly for locals who've built up a partial resistance to malaria from years of exposure. For safe-area-urbanites (such as most of us) it's supplemented with something else, such as Riamet (below).
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